Thyroid Hormone Receptors beta

**Definition:** High affinity receptors for THYROID HORMONES, especially TRIIODOTHYRONINE. These receptors are usually found in the nucleus where they regulate DNA transcription. They are encoded by the THRB gene (also known as NR1A2, THRB1, or ERBA2 gene) as several isoforms produced by alternative splicing. Mutations in the THRB gene cause THYROID HORMONE RESISTANCE SYNDROME.

**Tree numbers:** - D12.776.624.664.700.830.750 - D12.776.826.850.750

**Synonyms:** - c-erbA beta - TR beta - THRB Gene Products - ERBA2 Gene Products - NR1A2 Gene Products - Receptors beta, Thyroid Hormone - Thyroid Hormone Receptor beta