Calreticulin

**Definition:** A multifunctional protein that is found primarily within membrane-bound organelles. In the ENDOPLASMIC RETICULUM it binds to specific N-linked oligosaccharides found on newly-synthesized proteins and functions as a MOLECULAR CHAPERONE that may play a role in PROTEIN FOLDING or retention and degradation of misfolded proteins. In addition calreticulin is a major storage form for CALCIUM and functions as a calcium-signaling molecule that can regulate intracellular calcium HOMEOSTASIS.

**Tree numbers:** - D12.644.360.372.374 - D12.776.157.125.412.374 - D12.776.476.387.374 - D12.776.503.303

**Synonyms:** - CAB-63 - CBP3 (Liver) - ERp60 - 55-kDa High-Affinity Calcium Binding Protein - cC1qR Protein - Calcium-Binding Protein-3 - Calregulin - HACBP