Poly(A)-Binding Protein II

**Definition:** A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.

**Tree numbers:** - D12.776.157.725.452.500 - D12.776.664.962.452.500

**Synonyms:** - PAB II - PAB2 Poly(A) Binding Protein - Poly(A) Binding Protein II - Poly(A) Binding Protein, Nuclear 1 - PABP2 - Pabp2 Gene Product - Pabp2 Protein