Neural Cell Adhesion Molecule L1

**Definition:** A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.

**Tree numbers:** - D09.400.430.890.200.250.520.578 - D12.776.395.550.200.250.520.578 - D12.776.543.550.200.250.520.578 - D23.050.301.350.250.520.578

**Synonyms:** - NILE Glycoprotein - Nerve Growth Factor-Inducible Large External Glycoprotein - CALL Protein - CamL1 Gene Product - F11 Glycoprotein - NGF-Inducible Glycoprotein - L1CAM - NILE Protein - Cell Adhesion Molecule L1 - Cell Surface Glycoprotein L1 - Neural Adhesion Molecule L1 - L1 Cell Adhesion Molecule