Vascular Endothelial Growth Factor A

**Definition:** The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as tumor angiogenesis factor and vascular permeability factor. Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.

**Tree numbers:** - D12.644.276.100.800.200 - D12.776.467.100.800.200 - D23.529.100.800.200

**Synonyms:** - Vascular Endothelial Growth Factor - Vascular Endothelial Growth Factor-A - Vascular Permeability Factor - Vasculotropin - VEGF - VEGF-A