4-Quinolones

**Definition:** QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They inhibit the A subunit of DNA GYRASE and are used as antimicrobials. Second generation 4-quinolones are also substituted with a 1-piperazinyl group at the 7-position and a fluorine at the 6-position.

**Tree numbers:** - D03.633.100.810.835.830

**Synonyms:** - 4-Quinolone - 4-Quinolinone - 4-Oxoquinolines - 4-Quinolinones - 4-Oxoquinoline