Angiopoietin-2

**Definition:** An angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.

**Tree numbers:** - D12.644.276.100.100.200 - D12.776.467.100.100.200 - D23.529.100.100.200

**Synonyms:** - Angiopoietin 2