1-Alkyl-2-acetylglycerophosphocholine Esterase

**Definition:** A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.

**Tree numbers:** - D08.811.277.352.100.680.750.937.249

**Synonyms:** - PAF Acetylhydrolase II - Platelet-Activating Factor Hydrolase - Lipoprotein-Associated Phospholipase A(2) - Lipoprotein-Associated Phospholipase A2 - Lp-PLA(2) - Lp-PLA2 - PAF 2-Acetylhydrolase - PAF Acetylhydrolase - PAF 2-Acylhydrolase