Phosphodiesterase I

**Definition:** A phosphoric diester hydrolase that removes 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated OLIGONUCLEOTIDES. It has low activity towards POLYNUCLEOTIDES and the presence of 3'-phosphate terminus on the substrate may inhibit hydrolysis.

**Tree numbers:** - D08.811.277.352.640.430

**Synonyms:** - 5'-Exonuclease - 5'-Nucleotidephosphodiesterase - Alkaline Phosphodiesterase - Alkaline Phosphodiesterase I - Oligonucleate 5'-Nucleotidohydrolase - Orthophosphoric Diester Phosphohydrolase