alpha-Mannosidase

**Definition:** An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.

**Tree numbers:** - D08.811.277.450.625.500

**Synonyms:** - alpha-D-Mannosidase - alpha-D-Mannoside Mannohydrolase - Neutral alpha-Mannosidase