Receptor, Serotonin, 5-HT1D

**Definition:** A serotonin receptor subtype that is localized to the CAUDATE NUCLEUS; PUTAMEN; the NUCLEUS ACCUMBENS; the HIPPOCAMPUS, and the RAPHE NUCLEI. It plays a role as a terminal autoreceptor that regulates the rate of SEROTONIN release from nerve endings. This serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1B RECEPTOR, but is expressed at low levels. It is particularly sensitive to the agonist SUMATRIPTAN and may be involved in mediating the drug's antimigrane effect.

**Tree numbers:** - D12.776.543.750.670.800.100.200 - D12.776.543.750.695.800.100.200 - D12.776.543.750.720.670.100.750 - D12.776.543.750.720.850.100.200

**Synonyms:** - 5-HT1D Receptor - 5-Hydroxytryptamine1D Receptor - 5-HT(1D) Receptor - Serotonin 1D Receptors - Serotonin 1D Receptor - Receptor, Serotonin 1D