Receptor, PAR-2

**Definition:** A G-protein-coupled, proteinase-activated receptor that is expressed in a variety of tissues including ENDOTHELIUM; LEUKOCYTES; and the GASTROINTESTINAL TRACT. The receptor is activated by TRYPSIN, which cleaves off the N-terminal peptide from the receptor. The new N-terminal peptide is a cryptic ligand for the receptor. The uncleaved receptor can also be activated by the N-terminal peptide present on the activated THROMBIN RECEPTOR and by small synthetic peptides that contain the unmasked N-terminal sequence.

**Tree numbers:** - D12.776.543.750.695.035 - D12.776.543.750.792.249

**Synonyms:** - Trypsin Receptors - Trypsin Receptor - PAR-2 Receptor - Receptor, Trypsin - Proteinase Activated Receptor 2 - Protease-Activated Receptor 2 - PAR2 Receptor