Laron Syndrome

**Definition:** An autosomal recessive disorder characterized by short stature, defective GROWTH HORMONE RECEPTOR, and failure to generate INSULIN-LIKE GROWTH FACTOR I by GROWTH HORMONE. Laron syndrome is not a form of primary pituitary dwarfism (GROWTH HORMONE DEFICIENCY DWARFISM) but the result of mutation of the human GHR gene on chromosome 5.

**Tree numbers:** - C05.116.099.343.679 - C16.320.240.750 - C19.297.656

**Synonyms:** - Growth Hormone Receptor Defect - Growth Hormone Receptor Deficiency - Laron Dwarfism - Laron Type Dwarfism I - Growth Hormone Insensitivity Syndrome - Primary Growth Hormone Resistance - Severe GH Insensitivity - Pituitary Dwarfism II - Primary GH Resistance