Proteasome Endopeptidase Complex

**Definition:** A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.

**Tree numbers:** - D05.500.562.500 - D08.811.277.656.918 - D08.811.600.730

**Synonyms:** - Macroxyproteinase - Multicatalytic Endopeptidase Complex - Multicatalytic Proteinase - Prosome - Proteasome - Macropain - 20S Proteasome