Receptors, Tumor Necrosis Factor, Type I

**Definition:** A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. It is constitutively expressed in most tissues and is a key mediator of tumor necrosis factor signaling in the vast majority of cells. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.

**Tree numbers:** - D12.776.543.750.690.750 - D12.776.543.750.705.852.760.597

**Synonyms:** - CD120a Antigen - TNFR p60 - TNFR-I - Tumor Necrosis Factor Receptor Type I - TNFR1 - Tumor Necrosis Factor Receptor 1A - TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A) - Tumor Necrosis Factor Receptor Type 1 - Antigens, CD120a - CD120a Antigens - TNFRSF1A Receptor - Tumor Necrosis Factor Receptor Superfamily, Member 1A - CD 120a Antigen - Receptors, Tumor Necrosis Factor, Member 1A