14-3-3 Proteins

**Definition:** A large family of signal-transducing adaptor proteins present in wide variety of eukaryotes. They are PHOSPHOSERINE and PHOSPHOTHREONINE binding proteins involved in important cellular processes including SIGNAL TRANSDUCTION; CELL CYCLE control; APOPTOSIS; and cellular stress responses. 14-3-3 proteins function by interacting with other signal-transducing proteins and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the proteins.

**Tree numbers:** - D12.644.360.024.050 - D12.776.157.057.002 - D12.776.476.024.050

**Synonyms:** - Brain 14-3-3 Protein - Protein 14-3-3 - 14-3-3 Protein