Metabolic Detoxication, Phase II

**Definition:** The conjugation of exogenous substances with various hydrophilic substituents to form water soluble products that are excretable in URINE. Phase II modifications include GLUTATHIONE conjugation; ACYLATION; and AMINATION. Phase II enzymes include GLUTATHIONE TRANSFERASE and GLUCURONOSYLTRANSFERASE. In a sense these reactions detoxify phase I reaction products.

**Tree numbers:** - G03.171.450.750 - G03.787.225.450.750 - G07.690.725.225.450.750

**Synonyms:** - Metabolic Detoxification, Phase II - Metabolic Detoxication, Conjugative - Phase II Detoxification