TRPP Cation Channels

**Definition:** A subgroup of TRP cation channels that are widely expressed in various cell types. Defects are associated with POLYCYSTIC KIDNEY DISEASES. Polycystin-1 and Polycystin-2 form a heteromeric channel essential for regulation of CILIUM length and fluid-flow mechanosensation by the primary cilium in renal epithelium. Polycystin-2 can also function as a homotetramer and modulates calcium ion release from stimulated RYANODINE RECEPTORS in CARDIOMYOCYTES.

**Tree numbers:** - D12.776.157.530.400.150.900 - D12.776.157.530.400.901.777 - D12.776.543.585.400.150.900 - D12.776.543.585.400.901.777

**Synonyms:** - Polycystin - Polycystins