Serotonin Plasma Membrane Transport Proteins

**Definition:** Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. They are different than SEROTONIN RECEPTORS, which signal cellular responses to SEROTONIN. They remove SEROTONIN from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. Regulates signal amplitude and duration at serotonergic synapses and is the site of action of the SELECTIVE SEROTONIN REUPTAKE INHIBITORS.

**Tree numbers:** - D12.776.157.530.450.625.311 - D12.776.157.530.562.374.875 - D12.776.157.530.937.624 - D12.776.543.585.450.625.374 - D12.776.543.585.562.374.875 - D12.776.543.585.937.747

**Synonyms:** - Neurotransmitter Transporters, Serotonin-Specific - Neurotransmitter Transport Proteins, Serotonin-Specific - Serotonin Plasma Membrane Transporter Proteins - SERT Proteins - 5-Hydroxytryptamine Plasma Membrane Transport Protein - Serotonin Transporter