Squalene Monooxygenase

**Definition:** The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the first oxygenation step in the biosynthesis of STEROLS and is thought to be a rate limiting enzyme in this pathway. Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide.

**Tree numbers:** - D08.811.682.690.708.749

**Synonyms:** - Squalene Epoxidase - Squalene Monooxygenase (2,3-Epoxidizing)