Mannose-Binding Protein-Associated Serine Proteases

**Definition:** Serum serine proteases which participate in COMPLEMENT ACTIVATION. They are activated when complexed with the MANNOSE-BINDING LECTIN, therefore also known as Mannose-binding protein-Associated Serine Proteases (MASPs). They cleave COMPLEMENT C4 and COMPLEMENT C2 to form C4b2a, the CLASSICAL PATHWAY C3 CONVERTASE.

**Tree numbers:** - D08.811.277.656.300.760.501 - D08.811.277.656.959.350.501 - D12.776.124.486.274.045.387.875

**Synonyms:** - MASP Proteases - Mannose-Binding Protein-Associated Serine Protease - MBP-Associated Serine Protease - Mannan-Binding Lectin Serine Proteases - MBL-Associated Serine Proteases - MASP - MASPs