Succinate-Semialdehyde Dehydrogenase

**Definition:** An enzyme that plays a role in the GLUTAMATE and butanoate metabolism pathways by catalyzing the oxidation of succinate semialdehyde to SUCCINATE using NAD+ as a coenzyme. Deficiency of this enzyme, causes 4-hydroxybutyricaciduria, a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA).

**Tree numbers:** - D08.811.682.657.163.843

**Synonyms:** - NAD(+)-Dependent Succinic Semialdehyde Dehydrogenase - Succinate Semialdehyde Dehydrogenase - Succinic Semialdehyde Dehydrogenase