Complement C5b

**Definition:** The larger fragment generated from the cleavage of C5 by C5 CONVERTASE that yields COMPLEMENT C5A and C5b (beta chain + alpha' chain, the residual alpha chain, bound by disulfide bond). C5b remains bound to the membrane and initiates the spontaneous assembly of the late complement components to form C5b-8-poly-C9, the MEMBRANE ATTACK COMPLEX.

**Tree numbers:** - D12.776.124.486.274.450.625

**Synonyms:** - C5b Complement - Complement 5b - Complement Component 5b