NFATC Transcription Factors

**Definition:** A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.

**Tree numbers:** - D12.776.930.608

**Synonyms:** - NFATC Proteins - Nuclear Factor of Activated T-Cells, Cytoplasmic - NFAT Proteins - Nuclear Factors of Activated T-Cells - Transcription Factor NF-AT - NF-AT Proteins