STAT3 Transcription Factor

**Definition:** A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.

**Tree numbers:** - D12.644.360.024.342.300 - D12.776.157.057.186.300 - D12.776.476.024.430.300 - D12.776.930.840.300

**Synonyms:** - LIF-Response Factor - Acute-Phase Response Factor - IL6-Response Factor - Signal Transducer and Activator of Transcription 3 - APRF Transcription Factor - STAT3 Protein