STAT5 Transcription Factor

**Definition:** A signal transducer and activator of transcription that mediates cellular responses to a variety of CYTOKINES. Stat5 activation is associated with transcription of CELL CYCLE regulators such as CYCLIN KINASE INHIBITOR P21 and anti-apoptotic genes such as BCL-2 GENES. Stat5 is constitutively activated in many patients with acute MYELOID LEUKEMIA.

**Tree numbers:** - D12.644.360.024.342.500 - D12.776.157.057.186.500 - D12.776.476.024.430.500 - D12.776.930.840.500

**Synonyms:** - Signal Transducer and Activator of Transcription 5 - STAT5 Protein