Protein Inhibitors of Activated STAT

**Definition:** A family of structurally related proteins that are constitutively expressed and that negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. PIAS proteins inhibit the activity of signal transducers and activators of transcription.

**Tree numbers:** - D12.644.360.024.319 - D12.776.157.057.124 - D12.776.476.024.402

**Synonyms:** - PIAS Proteins