Sarcosine Dehydrogenase

**Definition:** A LIVER mitochondrial matrix flavoenzyme that catalyzes the oxidation of SARCOSINE to GLYCINE and FORMALDEHYDE. Mutation in the enzyme causes sarcosinemia, a rare autosomal metabolic defect characterized by elevated levels of SARCOSINE in BLOOD and URINE.

**Tree numbers:** - D08.811.682.662.582.550

**Synonyms:** - Monomethylglycine Dehydrogenase - Sarcosine N-Demethylase