Apoptosis Inducing Factor

**Definition:** A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.

**Tree numbers:** - D08.811.682.608.047 - D12.644.360.075.311 - D12.776.157.687.063 - D12.776.331.161 - D12.776.476.075.311 - D12.776.660.720.063

**Synonyms:** - AIF Apoptosis Regulatory Protein - Apoptosis-Inducing Factor - Mitochondrial Apoptosis-Inducing Factor