Proto-Oncogene Proteins c-akt

**Definition:** Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.

**Tree numbers:** - D08.811.913.696.620.682.700.755 - D12.776.476.563.755 - D12.776.624.664.700.168

**Synonyms:** - Protein Kinase B - Proto-Oncogene Protein RAC - Proto-Oncogene Protein Akt - Rac Protein Kinase - Protein-Serine-Threonine Kinase (Rac) - c-akt Proto-Oncogene Protein - akt Proto-Oncogene Protein - RAC-PK Protein - c-akt Protein - Related to A and C-Protein