PTEN Phosphohydrolase

**Definition:** A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.

**Tree numbers:** - D08.811.277.352.650.850 - D12.776.476.590 - D12.776.624.776.695

**Synonyms:** - PTEN Protein Phosphatase - PTEN Protein - PTEN Phosphatase - Mutated In Multiple Advanced Cancers 1 Protein - MMAC1 Protein - Phosphatase and Tensin Homologue on Chromosome Ten Protein