Plectin

**Definition:** A cytoskeletal linker protein with a molecular weight of greater than 500 kDa. It binds INTERMEDIATE FILAMENTS; MICROTUBULES; and ACTIN CYTOSKELETON and plays a central role in the organization and stability of the CYTOSKELETON. Plectin is phosphorylated by CALMODULIN KINASE; PROTEIN KINASE A; and PROTEIN KINASE C.

**Tree numbers:** - D12.776.220.790.750 - D12.776.744.736

**Synonyms:** - 500-kDa HD1 Protein - Hemidesmosomal Protein HD1