Wiskott-Aldrich Syndrome Protein Family

**Definition:** A family of microfilament proteins whose name derives from the fact that mutations in members of this protein family have been associated with WISKOTT-ALDRICH SYNDROME. They are involved in ACTIN polymerization and contain a polyproline-rich region that binds to PROFILIN, and a verprolin homology domain that binds G-ACTIN.

**Tree numbers:** - D05.750.078.730.912 - D12.776.220.525.912

**Synonyms:** - WAS Protein Family - WASP Protein Family