Cyclin-Dependent Kinase 2

**Definition:** A key regulator of CELL CYCLE progression. It partners with CYCLIN E to regulate entry into S PHASE and also interacts with CYCLIN A to phosphorylate RETINOBLASTOMA PROTEIN. Its activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P27 and CYCLIN-DEPENDENT KINASE INHIBITOR P21.

**Tree numbers:** - D08.811.913.696.620.682.700.646.500.750 - D12.776.167.200.323 - D12.776.476.563.646.500.750

**Synonyms:** - p33cdk2 Kinase - CDK2 Protein - Cdc2-Related Protein Kinase - Cdk2 Protein Kinase