Focal Adhesion Kinase 1

**Definition:** A non-receptor protein tyrosine kinase with PROTEIN PHOSPHATASE 1 regulatory activity that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.

**Tree numbers:** - D08.811.913.696.620.682.725.049.500 - D12.776.476.568.049.500 - D12.776.744.493

**Synonyms:** - Endogenous Substrate pp120 - p125FAK Protein - Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK - Protein Tyrosine Kinase 2