Cytochrome P-450 CYP3A

**Definition:** A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.

**Tree numbers:** - D08.244.453.860.500 - D08.811.682.662.582.353 - D08.811.682.690.708.170.495.500 - D12.776.422.220.453.860.500

**Synonyms:** - CYP3A - Cytochrome P-450IIIA - Cytochrome P450 3A - Erythromycin N-Demethylase