Proto-Oncogene Proteins c-bcr

**Definition:** A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.

**Tree numbers:** - D08.811.913.696.620.682.700.759 - D12.644.360.325.300.099.500 - D12.776.476.325.300.099.500 - D12.776.476.563.759 - D12.776.624.664.700.171

**Synonyms:** - Proto-Oncogene Protein c-bcr - Breakpoint Cluster Region Protein - Proto-Oncogene Protein bcr - c-bcr Proto-Oncogene Proteins - bcr Proto-Oncogene Proteins - c-bcr Proteins