Host Cell Factor C1

**Definition:** A cellular transcriptional coactivator that contains N-terminal KELCH REPEATS and N- and C-terminal FIBRONECTIN TYPE III DOMAINS. It functions as a transcription factor for a number of genes and in the assembly of IMMEDIATE-EARLY PROTEINS of the HERPES SIMPLEX VIRUS. Mutations in the HCFC1 gene are associated with cases of X-LINKED MENTAL RETARDATION.

**Tree numbers:** - D12.776.660.478 - D12.776.930.325

**Synonyms:** - HCFC1 Protein - C1 Host Cell Factor - Cell Proliferation Factor HCF