Caspase 2

**Definition:** A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.

**Tree numbers:** - D08.811.277.656.262.500.126.550.200 - D08.811.277.656.300.200.126.550.200 - D12.776.476.075.405.550.200

**Synonyms:** - Caspase-2 - ICH-1 Protease