Caspase 8

**Definition:** A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.

**Tree numbers:** - D08.811.277.656.262.500.126.550.800 - D08.811.277.656.300.200.126.550.800 - D12.776.157.057.018.037 - D12.776.476.024.320.025 - D12.776.476.075.405.550.800 - D12.776.476.075.421.037

**Synonyms:** - CAP4 Protease - FLICE Protein - MACH Protein - Mch5 Protease - Caspase-8