Osteoprotegerin

**Definition:** A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.

**Tree numbers:** - D12.776.543.750.705.852.760.949.249

**Synonyms:** - Osteoclastogenesis Inhibitory Factor - Receptors, Tumor Necrosis Factor, Member 11b - Tumor Necrosis Factor Receptor 11b - Tumor Necrosis Factor Receptor Superfamily, Member 11b - FDCR-1 Protein - OCIF Protein - Follicular Dendritic Cell-Derived Receptor-1