Apolipoprotein E4

**Definition:** A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.

**Tree numbers:** - D10.532.091.500.750 - D12.776.070.400.500.750 - D12.776.521.120.500.750

**Synonyms:** - Apo E epsilon 4 - Apo E-4 - Apo E4 - ApoE4 - Apolipoprotein E-4