PHEX Phosphate Regulating Neutral Endopeptidase

**Definition:** A membrane-bound metalloendopeptidase that may play a role in the degradation or activation of a variety of PEPTIDE HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Genetic mutations that result in loss of function of this protein are a cause of HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT.

**Tree numbers:** - D08.811.277.656.300.480.616 - D08.811.277.656.675.374.616 - D09.400.430.890.611 - D12.776.395.550.611 - D12.776.543.550.607

**Synonyms:** - Phosphate Regulating Neutral Endopeptidase - Phosphate Regulating Endopeptidase Homolog, X-Linked - X-Linked Phosphate Regulating Endopeptidase Homolog - PEX Phosphate Regulating Neutral Endopeptidase