Receptor-Interacting Protein Serine-Threonine Kinases

**Definition:** A family of serine-threonine kinases that plays a role in intracellular signal transduction by interacting with a variety of signaling adaptor proteins such as CRADD SIGNALING ADAPTOR PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 2; and TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN. Although they were initially described as death domain-binding adaptor proteins, members of this family may contain other protein-binding domains such as those involving caspase activation and recruitment.

**Tree numbers:** - D08.811.913.696.620.682.700.801 - D12.776.157.057.018.400 - D12.776.157.057.500.186 - D12.776.476.024.320.662 - D12.776.476.024.500.186 - D12.776.476.075.421.400 - D12.776.476.563.801

**Synonyms:** - RIP Serine-Threonine Kinases - RIPK (Ribosome Inactivating Proteins) - RIPK Ribosome Inactivating Proteins