High-Density Lipoproteins, Pre-beta

**Definition:** A highly dense subclass of the high-density lipoproteins, with particle sizes below 7 nm. They are also known as nascent HDL, composed of a few APOLIPOPROTEIN A-I molecules which are complexed with PHOSPHOLIPIDS. The lipid-poor pre-beta-HDL particles serve as progenitors of HDL3 and then HDL2 after absorption of free cholesterol from cell membranes, cholesterol esterification, and acquisition of apolipoproteins A-II, Cs, and E. Pre-beta-HDL initiate the reverse cholesterol transport process from cells to liver.

**Tree numbers:** - D10.532.432.550 - D12.776.521.479.602

**Synonyms:** - Nascent HDL - Pre-beta HDL - Pre-beta High-Density Lipoprotein - PreBeta-HDL - Lipoprotein, Pre-beta HDL