Gitelman Syndrome

**Definition:** An inherited renal disorder characterized by defective NaCl reabsorption in the convoluted DISTAL KIDNEY TUBULE leading to HYPOKALEMIA. In contrast with BARTTER SYNDROME, Gitelman syndrome includes hypomagnesemia and normocalcemic hypocalciuria, and is caused by mutations in the thiazide-sensitive SODIUM-POTASSIUM-CHLORIDE SYMPORTERS.

**Tree numbers:** - C12.050.351.968.419.815.491 - C12.200.777.419.815.491 - C12.950.419.815.491 - C16.320.831.491

**Synonyms:** - Potassium and Magnesium Depletion - Hypomagnesemia-Hypokalemia, Primary Renotubular, with Hypocalciuria - Hypokalemia-Hypomagnesemia, Primary Renotubular, with Hypocalciuria - Primary Renotubular, Hypomagnesemia-Hypokalemia with Hypocalciuria - Primary Renotubular, Hypokalemia-Hypomagnesemia with Hypocalciuria - Familial Hypokalemia-Hypomagnesemia - Gitelman's Syndrome - Tubular Hypomagnesemia-Hypokalemia with Hypocalcuria