Janus Kinase 2

**Definition:** A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.

**Tree numbers:** - D08.811.913.696.620.682.725.124.200 - D12.776.476.568.124.200 - D12.776.624.664.700.117

**Synonyms:** - JAK2 Protein Tyrosine Kinase - JAK-2 Protein Tyrosine Kinase