Receptor, Interferon alpha-beta

**Definition:** A ubiquitously expressed heterodimeric receptor that is specific for both INTERFERON-ALPHA and INTERFERON-BETA. It is composed of two subunits referred to as IFNAR1 and IFNAR2. The IFNAR2 subunit is believed to serve as the ligand-binding chain; however both chains are required for signal transduction. The interferon alpha-beta receptor signals through the action of JANUS KINASES such as the TYK2 KINASE.

**Tree numbers:** - D12.776.543.750.705.852.400.500

**Synonyms:** - Interferon alpha Receptor - Interferon alpha Receptors - Interferon alpha-beta Receptor - Interferon alphabeta Receptors - Receptor, Interferon alpha - Type I Interferon Receptor - IFN-alphaR - IFN-alphabetaR