Leukemia Inhibitory Factor Receptor alpha Subunit

**Definition:** A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.

**Tree numbers:** - D12.776.543.750.705.852.583.750 - D12.776.543.750.750.400.550.250.750

**Synonyms:** - Antigens, CD118 - CD118 Antigens - CD118 Antigen - LIF Receptor alpha Subunit