Transforming Growth Factor beta1

**Definition:** A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.

**Tree numbers:** - D12.644.276.374.687.100 - D12.644.276.954.775.100 - D12.776.467.374.687.100 - D12.776.467.942.775.100 - D23.529.374.687.100 - D23.529.942.775.100

**Synonyms:** - Transforming Growth Factor-beta1 - TGF-beta-1 - TGF-beta1 - Transforming Growth Factor beta I